A Brief Colonial History Of Ceylon(SriLanka)
Sri Lanka: One Island Two Nations
A Brief Colonial History Of Ceylon(SriLanka)
Sri Lanka: One Island Two Nations
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Thiranjala Weerasinghe sj.- One Island Two Nations
?????????????????????????????????????????????????Sunday, September 10, 2017
AstraZeneca rebuilds cancer drug hopes with new lung data
FILE
PHOTO: The logo of AstraZeneca is seen on medication packages in a
pharmacy in London, Britain April 28, 2014. REUTERS/Stefan Wermuth /File
Photo
MADRID (Reuters) - Two AstraZeneca drugs tackling lung cancer in
different ways delivered impressive clinical results on Saturday,
helping the British group offset July’s big clinical trial setback in
the disease.
Particularly notable was the success of the infused immunotherapy
medicine Imfinzi in helping non-small cell lung cancer patients with
inoperable mid-stage disease that has not spread widely around the body.
Chief Executive Pascal Soriot said it gave AstraZeneca a chance to
intervene earlier in lung cancer, distinguishing it from rivals that
have made more progress in tackling advanced or metastatic disease.
Results from a large clinical trial showed patients survived on average
16.8 months without their disease worsening when given Imfinzi, against
just 5.6 months for those on placebo.
Solange Peters of the Centre Hospitalier Universitaire Vaudois in
Lausanne, who was not involved in the study known as Pacific, told
Reuters the advantage of more than 11 months provided by Imfinzi was
“absolutely amazing”.
It is the first medicine to show superior progression-free survival in
such patients. These individuals typically receive a combination of
chemotherapy and radiotherapy, but only around 15 percent of them are
still alive after five years.
Significantly, while there were more reports of toxicity in patients
taking Imfinzi, the level of severe problems was similar in both groups.
“What we hear from the experts is that they think this is practice-changing,” Soriot told reporters.
AstraZeneca had already said Pacific and another study called Flaura met
their pre-defined goals, but the exact scale of the benefits was only
disclosed at the European Society for Medical Oncology (ESMO) congress
in Madrid.
The results were also published online in the New England Journal of Medicine.
Analysts believe using Imfinzi in so-called stage III lung cancer opens
up an annual sales opportunity worth around $2 billion. Importantly,
AstraZeneca has a lead of two to three years over rivals in this
particular area.
HIGHER SALES FORECASTS
Soriot said analyst forecasts were now likely to rise - and the initial
stock market reaction was positive, with AstraZeneca shares gaining 2
percent in extended trading after the results were unveiled late on
Friday U.S. time.
The stage III market is smaller than for advanced lung cancer, where a
combination of Imfinzi and tremelimumab failed to work as hoped in the
Mystic trial. That setback wiped $14 billion off AstraZeneca’s shares in
July.
Early success in Mystic would have given AstraZeneca the chance to
establish the first immunotherapy combination in advanced lung cancer,
ahead of rivals Bristol-Myers Squibb, Roche and Merck.
But Soriot says early-stage disease - where a cure is potentially
possible - is now a big opportunity for AstraZeneca, which is also
testing Imfinzi earlier than stage III.
“The early lung cancer population will grow with more cancer screening,” he said.
The Flaura trial, meanwhile, demonstrated the ability of AstraZeneca’s
new pill Tagrisso to hold lung cancer at bay in patients with a certain
genetic mutation that is particularly common in Asia.
The study showed Tagrisso, which AstraZeneca has predicted will become a
$4 billion-a-year seller, was significantly better than older medicines
that act in a similar way.
Patients on Tagrisso went 18.9 months on average before their disease
worsened, against 10.2 months for those given either Roche’s Tarceva or
AstraZeneca’s Iressa.
ESMO spokesman Enriqueta Felip of Spain’s Vall d’Hebron Institute of
Oncology said Tagrisso’s edge over older medicines and its good
tolerability meant it should be considered a new first-line treatment
option.