How Does the COVID Delta Variant Compare?

How Does the COVID Delta Variant Compare?

By Omri Wallach- October 29, 2021

In late 2020, a variant of COVID-19 was detected in India that began to quickly spread.

Soon after it received the label “Delta,” it started to become the predominant strain of COVID-19 in countries of transmission. It spread faster than both the original disease and other variants, including “Alpha” that had taken hold in the UK.

Now the COVID-19 pandemic has essentially become the Delta pandemic, as the variant accounts for more than 90% of global cases.

But how does the COVID-19 Delta variant differ from the original disease? We consolidated studies as of September 2021 to highlight key differences between COVID-19 and the dominant variant. Sources include the CDC, Yale Medicine, and the University of California.

COVID-19 vs COVID-19 Delta Variant

At first glance, infections caused by the Delta variant are similar to the original COVID-19 disease. Symptoms reported from patients include cough, fever, headache, and a loss of smell.

But studies showed that the difference was in how quickly and severely patients got sick:

• Spread rate: How quickly the infection spreads in a community (based on the R0 or basic reproductive number). The Delta variant spread 125% faster than the original disease, making it potentially as infectious as chickenpox.
• Viral load: How much of a virus is detectable in an infected person’s blood, with higher loads correlating with more severe infections. Delta infections had a 1000x higher viral load.
• Virus detectable: How long after exposure a virus is detectable in an infected person’s blood. Delta infections were found to be detectable four days after exposure, faster than the original disease (six days).
• Infectious period: How long an infected person has the capability to pass on the virus to other people, from the first time they were exposed. Delta infections were contagious for longer than traditional COVID-19 infections, at 18 days compared to 13 days.
• Risk of hospitalization: How much more or less likely is an infection going to require hospitalization for treatment? Infections caused by the Delta variant were twice as likely to cause hospitalization compared to the original disease.

One other important finding from studies was that the existing COVID-19 vaccines helped against Delta infections.

The CDC found that approved vaccines reduced the rate of infection by 5x and the rate of hospitalization by 29x in a breakthrough case. They also found that overall efficacy against infection can wane over time, however, and at-risk people might require a booster vaccine.

What About Other COVID-19 Variants?

Delta is just one of many COVID-19 variants tracked by health officials, but it’s the one we know the most about.

That’s because reliable statistics and information on diseases requires thousands of cases for comparisons. We know a lot about Delta (and the once-dominant UK strain Alpha) because of how widespread they became, but there haven’t been enough cases of other variants to reliably assess differences.

As of September 2021, WHO was tracking 20 COVID-19 variants around the world with different classifications based on potential severity:

• 14 Variants under monitoring (VUM): Variants that are deemed to not pose a major global health risk, or no longer pose one.
• 2 Variants of Interest (VOI): Variants that affect transmissibility, virulence, mutation, and other virus characteristics, and are spreading in clusters.
• 4 Variants of Concern (VOC): Have similar characteristics to VOI but are further associated with a global risk.

Most of the current variants of interest and concern were first identified and labeled in late 2020, though 2021 variants are showing up as well.

Label	Designation	Documented Origin	Earliest Identified Date
Alpha	Variant of Concern	UK	September 2020
Beta	Variant of Concern	South Africa	May 2020
Gamma	Variant of Concern	Brazil	November 2020
Delta	Variant of Concern	India	October 2020
Lambda	Variant of Interest	Peru	December 2020
Mu	Variant of Interest	Colombia	January 2021

Should you be worried about all of these variants? For the most part, a lack of cases to provide clear information also reflects that they’re equivalent to or weaker than traditional COVID-19 infections.

But it’s important to note that our understanding of diseases and variants becomes more nuanced and accurate over time. As research continues over a longer timeline and over a wider database of cases, expect information on COVID-19 variants (and any disease) to become more concrete.